Tetrahydrofuran → Cyclopropyl-(5-[(2,6-difluoro-3,5-dimethoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl)-amine
Reaction equation
[Al+3:28].[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH:1]1([NH:4][c:5]2[n:6][c:7]([S:25][CH3:26])[n:8][cH:9][c:10]2[CH:11]=[N:12][c:13]2[c:14]([F:24])[c:15]([O:22][CH3:23])[cH:16][c:17]([O:20][CH3:21])[c:18]2[F:19])[CH2:2][CH2:3]1.[H-:27].[H-:30].[H-:31].[H-:32].[Li+:29]>>[CH:1]1([NH:4][c:5]2[n:6][c:7]([S:25][CH3:26])[n:8][cH:9][c:10]2[CH2:11][NH:12][c:13]2[c:14]([F:24])[c:15]([O:22][CH3:23])[cH:16][c:17]([O:20][CH3:21])[c:18]2[F:19])[CH2:2][CH2:3]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-c4525e8f9e1f48f9a60c7ac0145dedf7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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