Hydrochloric Acid → HCID 68438180, compound

HRID 1438115Notes

Reaction equation

HRID 1438115 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([S:24]([CH:27]([CH3:29])[CH3:28])(=[O:26])=[O:25])=[C:6]([CH:8]2[CH:12]([C:13]([O:15][CH3:16])=[O:14])[CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)[CH:7]=1.[ClH:30]>O1CCOCC1>[ClH:30].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([S:24]([CH:27]([CH3:29])[CH3:28])(=[O:26])=[O:25])=[C:6]([CH:8]2[CH:12]([C:13]([O:15][CH3:16])=[O:14])[CH2:11][CH2:10][NH:9]2)[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57942794HCID 57942794, compound

Product 1

HCID 68438180HCID 68438180, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

20F was treated with 4.0 N HCl in dioxane for 4.0 h. After removal of solvent, 20G was obtained as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.62 (d, J=8.00 Hz, 1H) 6.6-6.9 (m, 2H) 5.1 and 5.0 (d, 1H) 3.2-3.5 (m, 3H) 3.0 (m, 1H) 2.1-2.4 (m, 2H) 1.32 (d, J=7.6 Hz, 3H) 1.22 (d, J=7.6 Hz, 3H).

Workup

  1. customAfter removal of solvent

Sources & evidence

ORD record
ord-b1a759c686d8442caa43c86ce2160b67
Source dataset
uspto-grants-2009_11
Patent number
US07622585B2

Reaction notes

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