反应详情

温度

50 °C

To a solution of 23A (4.4 g, 23 mmol) and K2CO3 (6.4 g, 46 mmol) in DMF (30 mL) was added ethyl iodide (2.49 mL, 31 mmol) at rt. The mixture was heated at 50° C. for 2.0 h. After cooling to rt, it was diluted with ether, washed with water and brine, dried over MgSO4. The crude residue was purified by flash column chromatography (EtOAc:hexanes=1:5) to give 3.86 g (77%) of 32A as viscous oil.

1. temperatureAfter cooling to rt
2. washwashed with water and brine
3. dry with materialdried over MgSO4
4. customThe crude residue was purified by flash column chromatography (EtOAc:hexanes=1:5)