反应详情

温度

45 °C

To 3-ethoxy-4-hydroxybenzaldehyde (20.0 g, 120 mmol) in dimethylformamide (250 mL) was added potassium carbonate (33.1 g, 240 mmol) then 2-iodopropane (18 mL, 180 mmol). The reaction mixture was heated to 45° C. and stirred for 3 h. After cooling to rt, the crude reaction mixture was extracted with ethyl acetate (3×). The combined extracts were then washed with water (3×) then brine and dried over sodium sulfate. The solvent was removed to give 24 g of 141A as a yellow oil. LC-MS: 231.17 (M+Na)+.

1. temperatureAfter cooling to rt
2. customthe crude reaction mixture
3. extractionwas extracted with ethyl acetate (3×)
4. washThe combined extracts were then washed with water (3×)
5. dry with materialbrine and dried over sodium sulfate
6. customThe solvent was removed