反应详情

温度

75 °C

Triazole (275 mg, 3.99 mmol) dissolved in anhydrous DMF (15 mL) was treated with NaH (60%, 153 mg). After 5 min, 4-bromo-1-bromomethyl-2-ethyl-benzene was added. The reaction mixture was heated to 75° C. for 5 hours before it was cooled to room temperature. The mixture was diluted with Et2O and washed with H2O, brine, dried over MgSO4. The solvent was removed in vacuo to afford the desired product (580 mg, 55% yield). 1H NMR (300 MHz, CDCl3): δ 1.10 (t, J=7.5 Hz, 3H), 2.68-2.73 (m, 2H), 5.46 (s, 2H), 7.01-7.04 (m, 1H), 7.38-7.46 (m, 2H), 7.97-8.01 (m, 2H).

1. temperaturewas cooled to room temperature
2. washwashed with H2O, brine
3. dry with materialdried over MgSO4
4. customThe solvent was removed in vacuo