Phenol → 5-Chloro-3-nitro-2-phenoxy-pyridine

HRID 1438419Notes

Reaction equation

HRID 1438419 reaction equation
Br[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([Cl:11])=[CH:4][N:3]=1.[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:11][C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([O:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:3][CH:4]=1

Participants

5

Reactant 3

HCID 996PhenolHCID 11430Potassium CarbonateHCID 2806812-Bromo-5-chloro-3-nitropyridine

Product 1

HCID 579424865-Chloro-3-nitro-2-phenoxy-pyridine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared according to the general procedure A described above using 2-bromo-5-chloro-3-nitro-pyridine (500 mg, 2.11 mmol), phenol (258 mg, 2.75 mmol), K2CO3 (437 mg, 3.16 mmol) and DMF (2 mL). MS m/z: 250.4 (M+H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-123eae725b4d4b4fae625101f0924028
Source dataset
uspto-grants-2009_11
Patent number
US07622583B2

Reaction notes

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