Acetic Acid → HCID 21400228, compound

HRID 1438700Notes

Reaction equation

HRID 1438700 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[NH:6][CH:5](SC)[N:4]([NH2:11])[C:3]1=[O:12].C(O)(=O)C.[CH3:17][NH2:18]>C(O)(C)C>[CH3:1][N:2]1[C:7](=[O:8])[NH:6][CH:5]([NH:18][CH3:17])[N:4]([NH2:11])[C:3]1=[O:12]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6329MethylamineHCID 53642864HCID 53642864, compound

Product 1

HCID 21400228HCID 21400228, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

18.8 g (0.1 mole) of 1-methyl-3-amino-4-methylmercaptotetrahydro-1,3,5-triazine-2,6-dione (prepared according to Example 2) were idssolved in 200 ml of isopropanol with addition of 6 g of glacial acetic acid and a pinch of ptoluenesulphonic acid and the mixture was saturated with methylamine gas at room temperature. The batch was left to stand for about 10 hours and was evaporated in vacuo, and the resudue was recrystallized from isopropanol. 15 g (88%) of 1-methyl-3-amino-4-methylamino-tetrahydro-1,3,5-triazine2,6-dione were obtained as a colorless powder; melting point 225°-227° C.

Workup

  1. waitThe batch was left
  2. customwas evaporated in vacuo
  3. customthe resudue was recrystallized from isopropanol

Sources & evidence

ORD record
ord-9033d03f3b2b4826a01a60825f5c1b9d
Source dataset
uspto-grants-1977_11
Patent number
US04056527

Reaction notes

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