Hydrochloric Acid → 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

HRID 1439032Notes

Reaction equation

HRID 1439032 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](O)([CH3:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1.Cl>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:20])=[CH:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 213225833-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

Product 1

HCID 540100683-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid is dissolved in 5 ml. of acetic acid. 1 ml. of concentrated hydrochloric acid is added and the mixture is allowed to stand for 2 hours at 20° and poured onto ice. After the customary work up, 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid, m.p. 193°-195°, is obtained.

Workup

  1. additionpoured onto ice

Sources & evidence

ORD record
ord-7485df1e7ebe4e5389b6f4c7ef2b4781
Source dataset
uspto-grants-1977_11
Patent number
US04057647

Reaction notes

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