Hydrochloric Acid → 4-(4-Chlorophenoxy)-1-methyl-3,5-diphenyl-1H-pyrazole

HRID 1439135Notes

Reaction equation

HRID 1439135 reaction equation
N([O-])=O.[Na+].N[C:6]1[CH:30]=[CH:29][C:9]([O:10][C:11]2[C:12]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[N:13][N:14]([CH3:22])[C:15]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:8][CH:7]=1.[ClH:31]>O>[Cl:31][C:6]1[CH:30]=[CH:29][C:9]([O:10][C:11]2[C:12]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[N:13][N:14]([CH3:22])[C:15]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 213981014-[(1-Methyl-3,5-diphenyl-1H-pyrazol-4-yl)oxy]anilineHCID 23668193Sodium Nitrite

Product 1

HCID 213980874-(4-Chlorophenoxy)-1-methyl-3,5-diphenyl-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of sodium nitrite (3.1 g, 0.0422 mole) in water (10 ml) is added slowly at 0° C to 5° C to a well stirred, chilled solution of 4-(p-aminophenoxy)-1-methyl-3,5-diphenylpyrazole (15.1 g, 0.0442 mole) in concentrated hydrochloric acid (50 ml).

Sources & evidence

ORD record
ord-72ddf36afaad4156b4a6aa9ced54660c
Source dataset
uspto-grants-1977_11
Patent number
US04058391

Reaction notes

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