Methane → HCID 21398374, compound

HRID 1439176Notes

Reaction equation

HRID 1439176 reaction equation
[C:1]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([NH2:19])[CH2:16][CH2:17][NH2:18].C>>[C:2]1([C:1]23[CH2:9][CH2:10][CH2:11][C:12](=[O:14])[N:18]2[CH2:17][CH2:16][CH2:15][NH:19]3)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 297MethaneHCID 4281,3-PropanediamineHCID 73914delta-Oxobenzenepentanoic acid

Product 1

HCID 21398374HCID 21398374, compound

Procedure

19.2 Parts of 4-benzoyl-butyric acid and 9 parts of 1,3-propanediamine are heated for 21/2 hours at 150°-160°. The reaction mixture is cooled to about 60°, extracted with hot ethyl acetate and the solution obtained is clarified over charcoal. On concentrating, the reaction product precipitates and is purified by recrystallisation from ethyl acetate. The melting point of the 9a-phenyl-octahydro-6H-pyrido[1,2-a]pyrimidin -6-one of the formula ##STR34## obtained is 142.5°. The following compound is obtained in an analogous manner:

Workup

  1. temperatureThe reaction mixture is cooled to about 60°
  2. extractionextracted with hot ethyl acetate
  3. customthe solution obtained
  4. concentrationOn concentrating
  5. customthe reaction product precipitates
  6. customis purified by recrystallisation from ethyl acetate

Sources & evidence

ORD record
ord-ae5907e8d6e84fe69245f20fc9bf205d
Source dataset
uspto-grants-1977_11
Patent number
US04058529

Reaction notes

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