Ethylene Glycol → HCID 21396507, compound

HRID 1439765Notes

Reaction equation

HRID 1439765 reaction equation
Cl[CH2:2][CH2:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)([OH:6])[CH3:5].[F-:20].[K+].C(O)CO>C(O)COCCO>[F:20][CH2:2][CH2:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)([OH:6])[CH3:5]

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 522689Potassium FluorideHCID 203028961-Chloro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol

Product 1

HCID 21396507HCID 21396507, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

A mixture of 27.9 g. of 1-chloro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol, 8.7 g. of KF, 10 ml. of ethylene glycol and 5 ml. of diethylene glycol is heated to 140° - 150° for 8 hours. It is cooled and worked up in the customary manner and gives 1-fluoro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol, m.p. 90° - 92°.

Workup

  1. additionA mixture of 27.9 g
  2. temperatureIt is cooled

Sources & evidence

ORD record
ord-670ec53042604fe69402d0bc91ee2e7c
Source dataset
uspto-grants-1977_11
Patent number
US04060633

Reaction notes

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