HCID 53828474, compound → HCID 14766834, compound

HRID 1439828Notes

Reaction equation

HRID 1439828 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3]>O1CCCC1.[Pd]>[CH2:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)=[CH:8][CH:9]=1)[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 53828474HCID 53828474, compound

Product 1

HCID 14766834HCID 14766834, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 10.6 g of 1-(p-n-propylphenyl)-2-(4'-fluorobiphenyl-4-yl)ethene [obtained by Heck coupling of 4-propylstyrene with 4-bromo-4'-n-fluorobiphenyl] in 200 ml of tetrahydrofuran is hydrogenated in the presence of Pd/C until the take-up H of is complete. Customary work-up gives 1-(p-propylphenyl)-2-(4'-fluorobiphenyl-4-yl)ethane, mp. 97°.

Sources & evidence

ORD record
ord-c81b1e84946848fe8b664e73e91ea2fc
Source dataset
uspto-grants-1996_03
Patent number
US05496499

Reaction notes

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