Dimethylformamide → 3-(4-chlorobenzylidene)-1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one

HRID 1439856Notes

Reaction equation

HRID 1439856 reaction equation
[NH:1]1[C:6](=[O:7])[CH2:5][S:4][C:3]2[CH:8]=[CH:9][C:10]3[C:15]([C:2]1=2)=[CH:14][CH:13]=[CH:12][CH:11]=3.[Cl:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.C[O-].[Na+].CN(C)C=O>O>[Cl:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[C:5]2[S:4][C:3]3[CH:8]=[CH:9][C:10]4[C:15]([C:2]=3[NH:1][C:6]2=[O:7])=[CH:14][CH:13]=[CH:12][CH:11]=4)=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 77264-ChlorobenzaldehydeHCID 10942334Sodium MethoxideHCID 138234521H-Naphtho[2,1-b][1,4]thiazin-2(3H)-one

Product 1

HCID 537645223-(4-chlorobenzylidene)-1H-naphtho[2,1-b][1,4]thiazin-2(3H)-oneYield 52.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one (5.17 g), 4-chlorobenzaldehyde (5.62 g), sodium methoxide (1.73 g) and dimethylformamide (80 ml) is refluxed for 4.5 hours. After cooling, the reaction mixture is poured into water and the resulting precipitate is separated by filtration, washed and dried and then is recrystallized from tetrahydrofuran-n-hexane to give 3-(4-chlorobenzylidene)-1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one (4.28 g). M.p. 277°-279° C.

Workup

  1. temperatureis refluxed for 4.5 hours
  2. temperatureAfter cooling
  3. customthe resulting precipitate is separated by filtration
  4. washwashed
  5. customdried
  6. customis recrystallized from tetrahydrofuran-n-hexane

Sources & evidence

ORD record
ord-958469ecbd8f4b42bd43a19b018246e4
Source dataset
uspto-grants-1996_03
Patent number
US05496815

Reaction notes

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