Methylparaben → HCID 12524442, compound

HRID 1439925Notes

Reaction equation

HRID 1439925 reaction equation
[Na].[OH:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1.[CH3:13][N:14]([CH3:18])[CH2:15]CO>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([O:9][CH2:10][CH2:13][N:14]([CH3:18])[CH3:15])=[O:8])=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 7456MethylparabenHCID 79022-(Dimethylamino)ethanolHCID 5360545Sodium

Product 1

HCID 12524442HCID 12524442, compound

Conditions

Temperature
110 °C

Procedure

In a first step, 1 g (43 mmol) of sodium was dissolved in 20 ml of 2-(dimethylamino)ethanol. An amount of 3.0 g (22 mmol) of methyl 4-hydroxybenzoate was added and heated to 110° C. for 24 hours and then cooled to room temperature. The solvent was removed under reduced pressure and using a column chromatography (silica gel, chloroform-methanol), a white solid of 2-(dimethylamino)-ethyl 4-hydroxybenzoate was obtained.

Workup

  1. temperaturecooled to room temperature
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0b0afa54ac674d848c14e2b846dbb873
Source dataset
uspto-grants-1996_03
Patent number
US05496854

Reaction notes

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