反应详情

温度

80 °C

A 400 mg amount of 7-amino -2,2,6-trimethyl-2,3-dihydrobenzofuran was dissolved in 10 ml of carbon tetrachloride, and 246 mg of triphosgene was added thereto. The reaction solution was heated to 80° C., and 229 mg of triethylamine was slowly added thereto with stirring. Further, the mixture was heated under reflux for 1.5 hr. The reaction mixture was filtered through Celite to remove insolubles. The solvent was removed by evaporation to provide 461 mg of the title compound.

1. temperatureFurther, the mixture was heated
2. temperatureunder reflux for 1.5 hr
3. filtrationThe reaction mixture was filtered through Celite
4. customto remove insolubles
5. customThe solvent was removed by evaporation