Hydrochloric Acid → HCID 70285340, compound

HRID 1440021Notes

Reaction equation

HRID 1440021 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:18]3[CH2:22][CH2:21][CH:20]([NH:23]C(=O)C)[CH2:19]3)[CH:16]=2)[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]1.C(O)C.[ClH:35]>O>[ClH:35].[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:18]3[CH2:22][CH2:21][CH:20]([NH2:23])[CH2:19]3)[CH:16]=2)[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 18985305HCID 18985305, compound

Product 1

HCID 70285340HCID 70285340, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.5 g of 1-(3-fluoro-4-pyridyl)-6-fluoro-7-(3-acetamido-1-pyrrolidyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is added to 15 ml of ethanol, 10 ml of water and 5 ml of conc. hydrochloric acid. The reaction mixture is refluxed for 18 hours, cooled and concentrated under a reduced pressure to remove the solvent completely.

Workup

  1. temperatureThe reaction mixture is refluxed for 18 hours
  2. temperaturecooled
  3. concentrationconcentrated under a reduced pressure
  4. customto remove the solvent completely

Sources & evidence

ORD record
ord-2bf61209620b4f199d961388e48e93b2
Source dataset
uspto-grants-1996_03
Patent number
US05496947

Reaction notes

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