反应详情

3.1 g (20 mmol) of n-propyl bromide was dripped into a mixture of 0.5 g (21 mmol) of magnesium and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 6.8 g (20 mmol) of 1-chloro-4-(trans-4-(2-(4-fluorophenyl) ethyl) cyclohexyl)-1-silacyclohexane. The silacyclohexane rings of the reacted mixture thus obtained were a mixture of trans isomers and cis isomers. After a conventional after treatment, they were separated by means of chromatography to obtain 6.4 g (yield 85%) of trans-4-(trans-4-(2-(4-fluorophenyl) ethyl) cyclohexyl)-1-n-pentyl-1-silacyclohexane.

1. customto obtain a Grignard's reagent
2. customThe silacyclohexane rings of the reacted mixture thus obtained
3. additiona mixture of trans isomers and cis isomers
4. customAfter a conventional after treatment, they were separated by means of chromatography