Sodium Bicarbonate → HCID 18983817, compound

HRID 1440466Notes

Reaction equation

HRID 1440466 reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]2[C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=[CH:7][N:6]2[CH:16]=1.C(=O)(O)[O-].[Na+]>Cl>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]2[C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=[CH:7][N:6]2[CH:16]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 18983824HCID 18983824, compound

Product 1

HCID 18983817HCID 18983817, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Ethyl 2-chloromethylimidazo[1,2-a]pyridine-8-carboxylate (8.4 g, 35.2 m moles) was added to conc. hydrochloric acid 1100 ml), and the mixture was refluxed under heating for 5 hours. The reaction mixture was cooled to room temperature and adjusted to pH 4 with saturated aqueous solution of sodium bicarbonate. The precipitating crystals were collected by filtration to give the object compound (5.67 g, yield 98.4%) as crystal. m.p. 250° C. (decomp.).

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 5 hours
  3. filtrationThe precipitating crystals were collected by filtration

Sources & evidence

ORD record
ord-649b9f5991824af6ad061cfa36939505
Source dataset
uspto-grants-1996_03
Patent number
US05498774

Reaction notes

Loading…