反应详情

A flat bottomed vial was charged with a mixture of 1-chloro-1-(4-isobutylphenyl)ethane (500 mg; 2.54 mmol), 250 mg (11 mmol) of sodium spheres in 5 mL of dry dimethylformamide. The vial was immersed in an ultrasound cleaner filled with water, and sonicated at room temperature for 2 hours. The reaction mixture was carefully treated with 30 mL of water and extracted with ether (3×30 mL). The ether extract was washed with water (3 ×15 mL) and dried over anhydrous MgSO4. It was filtered and stripped off the solvent to obtain 382 mg (94% yield) of pure 4-isobutylstyrene.

1. customsonicated at room temperature for 2 hours
2. extractionextracted with ether (3×30 mL)
3. extractionThe ether extract
4. washwas washed with water (3 ×15 mL)
5. dry with materialdried over anhydrous MgSO4
6. filtrationIt was filtered