反应详情

A solution of 2-chloro-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline (3.00 g), 4-(4-bromophenoxy)-3-phenylpiperidine (5.20 g), triethylamine (1.62 g) and dimethylformamide (50 ml) was stirred at 115° C., under nitrogen, overnight. The solution was poured onto ice water (600 ml) and the precipitate was collected. The precipitate was dissolved in dichloromethane and the solution was washed with brine, dried over anhydrous magnesium sulfate, filtered, and the filtrate was evaporated. The residue was triturated with ethyl acetate and then recrystallized from chloroform-ether to give 4.25 g (56%) of product, mp 188°-189° C.

1. additionThe solution was poured onto ice water (600 ml)
2. customthe precipitate was collected
3. dissolutionThe precipitate was dissolved in dichloromethane
4. washthe solution was washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customthe filtrate was evaporated
8. customThe residue was triturated with ethyl acetate
9. customrecrystallized from chloroform-ether