Methyl iodide → HCID 21475729, compound

HRID 1440763Notes

Reaction equation

HRID 1440763 reaction equation
COC1C=CC(/C=[C:16]2/[C:17]([NH:19][C:20]([S:22]/2)=[NH:21])=[O:18])=CC=1OC1CCCC1.C[I:24].[C:25](OCC)(=O)C>CN(C)C=O>[IH:24].[CH3:25][N:19]1[C:17](=[O:18])[CH2:16][S:22][C:20]1=[NH:21]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 137629131(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

Product 1

HCID 21475729HCID 21475729, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

11.6 g (0.1 mol) of pseudothiohydantoin was suspended in 150 ml of dimethylformamide, and 17 g (0.12 mol) of methyl iodide was added thereto. Then, the mixture was stirred at 60° C. for one hour. After being left to cool, the reaction mixture was poured into 1000 ml of ethyl acetate, and precipitated crystals were collected by filtration to obtain 15 g of 3-methyl-2-iminothiazolidin-4-one hydroiodide as pale yellow crystals.

Workup

  1. waitAfter being left
  2. temperatureto cool
  3. customprecipitated crystals
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-5fc93658ce0d47789fab0bd0cdae3fd4
Source dataset
uspto-grants-1996_03
Patent number
US05500406

Reaction notes

Loading…