Tri-o-tolylphosphine → HCID 22859562, compound

HRID 1441063Notes

Reaction equation

HRID 1441063 reaction equation
[N:1]1[CH:6]=[C:5]([Sn](CCCC)(CCCC)CCCC)[CH:4]=[N:3][CH:2]=1.Br[C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][C@H:31]1[CH2:35][CH2:34][CH2:33][N:32]1[CH2:36][CH:37]1[CH2:39][CH2:38]1.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C>>[CH:37]1([CH2:36][N:32]2[CH2:33][CH2:34][CH2:35][C@@H:31]2[CH2:30][C:24]2[C:23]3[C:27](=[CH:28][CH:29]=[C:21]([C:5]4[CH:4]=[N:3][CH:2]=[N:1][CH:6]=4)[CH:22]=3)[NH:26][CH:25]=2)[CH2:39][CH2:38]1

Participants

4

Reactant 3

HCID 80271Tri-o-tolylphosphineHCID 27632495-(Tributylstannyl)pyrimidineHCID 22859588HCID 22859588, compound

Product 1

HCID 22859562HCID 22859562, compound

Procedure

(5-Pyrimidinyl)tri-n-butylstannane (see Preparation 45) and 5-bromo-3-(1-cyclopropylmethylpyrrolidin-2(R)-ylmethyl)-1H-indole (see Preparation 56) were reacted together in the presence of palladium (II) acetate Pd(OAc)2 !, tri-o-tolylphosphine (o-TI)3P! and triethylamine (C2H5)3N! using a procedure similar to that described in Example 1. This yielded the title compound. Found: C,73.72; H,7.53; N,15.84; C21H24N4.1/8CH2Cl2.1/8H2O requires: C,73.47; H,7.15; N,16.23%.

Sources & evidence

ORD record
ord-583629d0b7034c76870b9a6e7173a665
Source dataset
uspto-grants-1996_03
Patent number
US05502065

Reaction notes

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