Aluminium lithium hydride → HCID 54426322, compound

HRID 1441068Notes

Reaction equation

HRID 1441068 reaction equation
C[O:2][C:3]([C:5]1[O:9][C:8]([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][CH:14]=[C:13]3[CH2:19][C@H:20]2[CH2:24][CH2:23][CH2:22][N:21]2[CH3:25])=[CH:7][CH:6]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[OH:2][CH2:3][C:5]1[O:9][C:8]([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][CH:14]=[C:13]3[CH2:19][C@H:20]2[CH2:24][CH2:23][CH2:22][N:21]2[CH3:25])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22859581HCID 22859581, compound

Product 1

HCID 54426322HCID 54426322, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(5-Methoxycarbonyl-2-furyl)-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole (see Example 65) was reacted with lithium aluminium hydride, in tetrahydrofuran, using a procedure similar to that described in Example 63. This gave the title compound. Found: C,70.59; H,6.81; N,8.41. C19H22N2O2.3/16CH2Cl2 requires: C,70.62; H,6.91; N,8.59%.

Sources & evidence

ORD record
ord-f37bdcd1d2b94eb3a10cac1c894b9216
Source dataset
uspto-grants-1996_03
Patent number
US05502065

Reaction notes

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