Hydrochloric Acid → HCID 68540965, compound

HRID 1441270Notes

Reaction equation

HRID 1441270 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([NH2:17])=[O:16])[C@H:10]([CH3:18])[CH2:9]1)(OC(C)(C)C)=O.[ClH:19]>O1CCOCC1>[ClH:19].[CH3:18][C@@H:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[CH2:14][C:15]([NH2:17])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68539905HCID 68539905, compound

Product 1

HCID 68540965HCID 68540965, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of (R)-2-(4-Boc-2-methylpiperazin-1-yl)acetamide (114 mg, 0.44 mmol) and 5N hydrochloric acid (0.2 ml) in 1,4-dioxane (2.0 ml) was stirred at 90° C. for 20 min. The mixture was concentrated in vacuo to afford (R)-2-(2-methylpiperazin-1-yl)acetamide hydrochloride salt quantitatively.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1fbf13db4ce44e3ab7267945123403c1
Source dataset
uspto-grants-2010_02
Patent number
US07655645B2

Reaction notes

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