HCID 68697397, compound → HCID 68700878, compound

HRID 1441279Notes

Reaction equation

HRID 1441279 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[N:11]1[CH2:20][C:19]2[C:14](=[N:15][C:16]([S:21]([CH3:24])(=[O:23])=[O:22])=[N:17][CH:18]=2)[N:13]([CH3:25])[C:12]1=[O:26].[H][H]>O1CCCC1>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16]([S:21]([CH3:24])(=[O:22])=[O:23])=[N:17][CH:18]=3)[N:13]([CH3:25])[C:12]2=[O:26])[CH:4]=1

Participants

4

Reactant 2

HCID 68697397HCID 68697397, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68700878HCID 68700878, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5.94 g 3-(2-chloro-5-nitro-phenyl)-7-methanesulfonyl-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one were dissolved in 200 mL tetrahydrofuran. Pd(CaCO3)/C was added to the solution which was then treated with hydrogen (1 atm) for 18 h. The solution was then filtrated and the solvent evaporated. The residue was extracted with diethyl ether and the title product obtained in 98% yield.

Workup

  1. filtrationThe solution was then filtrated
  2. customthe solvent evaporated
  3. extractionThe residue was extracted with diethyl ether

Sources & evidence

ORD record
ord-1cc9c2b86cc44305a098f669972c8618
Source dataset
uspto-grants-2010_02
Patent number
US07655651B2

Reaction notes

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