Triethylamine → HCID 58878501, compound

HRID 1441660Notes

Reaction equation

HRID 1441660 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].S(Cl)(Cl)=O.[Br:21][C:22]1[CH:27]=[C:26]([CH:28]([CH3:30])[CH3:29])[CH:25]=[CH:24][C:23]=1[NH2:31].C(N(CC)CC)C>C(Cl)Cl.CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:16])[NH:31][C:23]2[CH:24]=[CH:25][C:26]([CH:28]([CH3:29])[CH3:30])=[CH:27][C:22]=2[Br:21])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

8

Reactant 4

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 5213372-Bromo-4-isopropylaniline

Product 1

HCID 58878501HCID 58878501, compound

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1049PyridineSolventHCID 6344DichloromethaneSolvent2×

Procedure

Piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (2.97 g, 13 mmol) was dissolved in dry methylene chloride (25 mL) and dry pyridine (2.7 mL). To the reaction mixture was then added thionyl chloride (1.86 g, 15.6 mmol) under nitrogen atmosphere and the reaction mixture was stirred at room temperature for 30 minutes. To the reaction mixture was then added successively, under nitrogen atmosphere, 2-bromo-4-isopropyl-phenylamine (3.0 g, 14 mmol), dry triethylamine (4.6 g, 45.5 mmol), dry methylene chloride (20 mL), 4-(dimethylamino)pyridine (0.16 g, 1.3 mmol) and the reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was then partitioned with aqueous 2N HCl and tert-Butyl methyl ether. The organic layer was washed with aqueous 2N HCl, aqueous NaHCO3, brine, dried with Na2SO4, filtered and the solvent evaporated in vacuo to yield a crude oil. The crude oil was recrystallized from ethyl acetate/hexanes to yield the title compound as a solid.

Workup

  1. additionTo the reaction mixture was then added successively, under nitrogen atmosphere
  2. customThe reaction mixture was then partitioned with aqueous 2N HCl and tert-Butyl methyl ether
  3. washThe organic layer was washed with aqueous 2N HCl, aqueous NaHCO3, brine
  4. dry with materialdried with Na2SO4
  5. filtrationfiltered
  6. customthe solvent evaporated in vacuo
  7. customto yield a crude oil
  8. customThe crude oil was recrystallized from ethyl acetate/hexanes

Sources & evidence

ORD record
ord-8e6e4b01571d4085839358402afce777
Source dataset
uspto-grants-2010_02
Patent number
US07655670B2

Reaction notes

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