反应详情

温度

21 °C

A mixture of quinolin-6-ol (0.29 g., 2 mmol), heptyl isocyanate (0.39 ml, 2.4 mmol) and pyridine (2 ml) in dry tetrahydrofuran (10 ml) was stirred at room temperature (21° C.) for 40 hours, the reaction mixture was concentrated under vaccum and the residue was washed with water (2×5 ml) and crystallized with ether to give 1b; yield: 0.30 g. (52.4%).

1. concentrationthe reaction mixture was concentrated under vaccum
2. washthe residue was washed with water (2×5 ml)
3. customcrystallized with ether