Methanol → HCID 58868898, compound

HRID 1441978Notes

Reaction equation

HRID 1441978 reaction equation
[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:25]2=[CH:28][C:10]=1[CH2:11][C@H:12]([NH:65][C:66]([O:68][CH2:69][C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1)=[O:67])[C:13](=[O:64])[NH:14][C@@H:15]([CH2:42][C@@H:43]([O:56][Si:57]([C:60]([CH3:63])([CH3:62])[CH3:61])([CH3:59])[CH3:58])[CH2:44][NH:45][C:46]([O:48][CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)=[O:47])[C:16](=[O:41])[NH:17][C@H:18]([C:31]([O:33]CC1C=CC=CC=1)=[O:32])[CH2:19][C:20]1[CH:29]=[C:24]2[CH:23]=[CH:22][C:21]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.CO.[OH-].[Li+]>C1COCC1>[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:25]2=[CH:28][C:10]=1[CH2:11][C@H:12]([NH:65][C:66]([O:68][CH2:69][C:70]1[CH:71]=[CH:72][CH:73]=[CH:74][CH:75]=1)=[O:67])[C:13](=[O:64])[NH:14][C@@H:15]([CH2:42][C@@H:43]([O:56][Si:57]([C:60]([CH3:63])([CH3:62])[CH3:61])([CH3:59])[CH3:58])[CH2:44][NH:45][C:46]([O:48][CH2:49][C:50]1[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=1)=[O:47])[C:16](=[O:41])[NH:17][C@H:18]([C:31]([OH:33])=[O:32])[CH2:19][C:20]1[CH:29]=[C:24]2[CH:23]=[CH:22][C:21]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 58868828HCID 58868828, compound

Product 1

HCID 58868898HCID 58868898, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

220 mg (0.21 mmol) of the compound from Example 25C are dissolved in 11 ml of THF, and 3 ml each of water and methanol are added. After the addition of 10.2 mg (0.43 mmol) of lithium hydroxide the mixture is stirred at RT for 24 h. The reaction solution is then concentrated in vacuo, and the crude product is dried under high vacuum.

Workup

  1. concentrationThe reaction solution is then concentrated in vacuo
  2. dry with materialthe crude product is dried under high vacuum

Sources & evidence

ORD record
ord-c10cc867c8a7430f8b305ce6ae8145e6
Source dataset
uspto-grants-2010_02
Patent number
US07655643B2

Reaction notes

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