Diisopropyl Ether → HCID 58610110, compound

HRID 1442589Notes

Reaction equation

HRID 1442589 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[CH:13]=[C:14]([CH2:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:15]=[CH:16][CH:17]=2)=[N:3]1.C(OC(C)C)(C)C>FC(F)(F)C(O)=O>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[CH:13]=[C:14]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH:15]=[CH:16][CH:17]=2)=[N:3]1

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 23085229HCID 23085229, compound

Product 1

HCID 58610110HCID 58610110, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

After tert-butyl 3-[3-(4-oxo-4H-1,3-benzothiazin-2-yl)phenyl]propionate (0.19 g, 0.52 mmol) was dissolved in trifluoroacetic acid (1.0 ml), the mixture was stirred at room temperature for 2 hours. Isopropyl ether was added to the reaction solution and the precipitated crystals were taken by filtration. The precipitates were recrystallized from ethanol-isopropyl ether to give the title compound (0.056 g, 35%) as crystals.

Workup

  1. filtrationthe precipitated crystals were taken by filtration
  2. customThe precipitates were recrystallized from ethanol-isopropyl ether

Sources & evidence

ORD record
ord-0dcb9daa64c54469aa02cb6ae94f21c9
Source dataset
uspto-grants-2010_02
Patent number
US07659267B2

Reaction notes

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