Triethylamine → HCID 9903389, compound

HRID 1442590Notes

Reaction equation

HRID 1442590 reaction equation
[C:1](#[N:10])[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[CH:3]=1.[C:11](OC)(=[O:19])[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[SH:14].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:5]([C:4]1[CH:3]=[C:2]([C:1]2[S:14][C:13]3[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=3[C:11](=[O:19])[N:10]=2)[CH:9]=[CH:8][CH:7]=1)#[N:6]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12276IsophthalonitrileHCID 21009Benzoic acid, 2-mercapto-, methyl ester

Product 1

HCID 9903389HCID 9903389, compoundYield 3.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of isophthalonitrile (1.00 g, 07.8 mmol), methyl thiosalicylate (1.97 g, 12 mmol), triethylamine (1.34 g, 13 mmol) and toluene (5 ml) was heated and refluxed for 5 hours under a nitrogen flow. The precipitated crystals were taken by filtration and recrystallized from tetrahydrofuran-ethanol to give the title compound (0.07 g, 2%) as crystals.

Workup

  1. temperaturewas heated
  2. temperaturerefluxed for 5 hours under a nitrogen flow
  3. filtrationThe precipitated crystals were taken by filtration
  4. customrecrystallized from tetrahydrofuran-ethanol

Sources & evidence

ORD record
ord-55720152173f46a7b04ab0e854420e03
Source dataset
uspto-grants-2010_02
Patent number
US07659267B2

Reaction notes

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