Hydrochloric Acid → HCID 67266386, compound

HRID 1442859Notes

Reaction equation

HRID 1442859 reaction equation
C(OC(=O)C[C:8]1([C:17]([OH:19])=[O:18])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9]1)(C)(C)C.Cl>CCOC(C)=O>[C:17]([CH2:8][CH:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]1[C:17]([OH:19])=[O:18])([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15298916HCID 15298916, compound

Product 1

HCID 67266386HCID 67266386, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-(2-tert-butoxy-2-oxoethyl)indane-2-carboxylic acid from Step B (1.50 g, 5.43 mmol) in EtOAc (100 mL) was saturated with HCl (g) and aged at ambient temperature for 1 h, then concentrated to dryness in vacuo to give the title compound. MS: m/z=284 (M+Na+CH3CN).

Workup

  1. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-b68a435e64f642f88338a66c921717f3
Source dataset
uspto-grants-2010_02
Patent number
US07659300B2

Reaction notes

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