HCID 86628006, compound → HCID 18442652, compound

HRID 1442876Notes

Reaction equation

HRID 1442876 reaction equation
[CH:1]1([CH2:4][N:5]2[C:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:8][N:7]([CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])[C:6]2=[O:24])[CH2:3][CH2:2]1>C(Cl)Cl.C(C(O)=O)(F)(F)F>[CH:1]1([CH2:4][N:5]2[C:9]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:8][N:7]([CH2:16][C:17]([OH:19])=[O:18])[C:6]2=[O:24])[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 86628006HCID 86628006, compound

Product 1

HCID 18442652HCID 18442652, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl [3-(cyclopropylmethyl)-2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl]acetate from Step C (41 mg, 0.125 mmol) in CH2Cl2 (2 mL) and CF3CO2H (1 mL) was stirred at ambient temperature for 3 h. The mixture was concentrated in vacuo to afford the title compound. MS: m/z=273 (M+1).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a26f9f60f4da4ae78cc9aa3f41c4f874
Source dataset
uspto-grants-2010_02
Patent number
US07659300B2

Reaction notes

Loading…