Diethyl Ether → HCID 59166752, compound

HRID 1442956Notes

Reaction equation

HRID 1442956 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)[CH2:10][CH:9]1[C:21]([OH:23])=[O:22])=O)(C)(C)C.CCOCC>Cl.O1CCOCC1>[Cl:20][C:16]1[CH:15]=[C:14]([NH:13][C@@H:11]2[CH2:12][NH:8][C@H:9]([C:21]([OH:23])=[O:22])[CH2:10]2)[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 2

HCID 3283Diethyl EtherHCID 68544435HCID 68544435, compound

Product 1

HCID 59166752HCID 59166752, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

4-(3-Chloro-phenylamino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (Preparation 41, 155 mg, 0.456 mmol) was stirred in 4 M HCl in dioxan (4 ml) at 0° C. for 2 hours. Ether (4 ml) was added and the resultant white hygroscopic solid filtered off and dried in vacuo at 40° C. to give the title compound (90 mg, 60.3%).

Workup

  1. filtrationthe resultant white hygroscopic solid filtered off
  2. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-ab1d8cdf88ee43fdb60eb2592db6950c
Source dataset
uspto-grants-2010_02
Patent number
US07659305B2

Reaction notes

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