2-Fluorophenol → HCID 68541642, compound

HRID 1443070Notes

Reaction equation

HRID 1443070 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[OH:8])[CH2:2]1.BrC1C=NC=CC=1.[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1O>>[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:8][C@@H:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C@H:3]1[O:4][CH2:5][CH2:6][NH:1][CH2:2]1

Participants

4

Reactant 3

HCID 97072-FluorophenolHCID 122863-BromopyridineHCID 68542861HCID 68542861, compound

Product 1

HCID 68541642HCID 68541642, compound

Procedure

(S)-2-[(S)-(2-Fluorophenoxy)-pyridin-3-yl-methyl]-morpholine was synthesized via morpholin-2-yl-pyridin-3-yl-methanol from 3-bromopyridine and 2-fluorophenol according to general procedure C and was isolated as a gummy oil (mixture of diastereoisomers). MS (APCI): 289 [M+H]+.

Workup

  1. customwas isolated as a gummy oil (mixture of diastereoisomers)

Sources & evidence

ORD record
ord-10173180ca2b40058fae4f2e37f13b7e
Source dataset
uspto-grants-2010_02
Patent number
US07659394B2

Reaction notes

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