Dimethylformamide dimethyl acetal → 5-nitro-1H-isochromen-1-one

HRID 1443123Notes

Reaction equation

HRID 1443123 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[CH3:13].COC(OC)N(C)C>CN(C)C=O>[N+:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]2[C:5]=1[CH:13]=[CH:1][O:2][C:3]2=[O:14])([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 601165Methyl 2-methyl-3-nitrobenzoate

Product 1

HCID 100127605-nitro-1H-isochromen-1-oneYield 54.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

16.4 g (84.03 mmol) of the 2-methyl-3-nitrobenzoic acid methyl ester that is described under Example 1 is stirred with 26.8 g (225.1 mmol) of N,N-dimethylformamide dimethylacetal in 85 ml of dimethylformamide for 12 hours at 130° C. The solvent is drawn off in a rotary evaporator, the residue is taken up in methyl tert-butyl ether and washed three times with water. After washing with saturated NaCl solution, the organic phase is dried. After the desiccant is filtered off and the solvent is spun off, the remaining residue is chromatographed on silica gel (mobile solvent:ethyl acetate/hexane). 8.73 g (54.4%) of the desired compound is isolated.

Workup

  1. customThe solvent is drawn off in a rotary evaporator
  2. washwashed three times with water
  3. washAfter washing with saturated NaCl solution
  4. customthe organic phase is dried
  5. filtrationAfter the desiccant is filtered off
  6. customthe remaining residue is chromatographed on silica gel (mobile solvent:ethyl acetate/hexane)

Sources & evidence

ORD record
ord-ca49eb65d45b432186a1781b622e9069
Source dataset
uspto-grants-2010_02
Patent number
US07659297B2

Reaction notes

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