反应详情

A solution of LiOH (105 mg in 4 mL, of water) was added at 0° C. to the lactone amide (65). After 1 h, the conversion was completed (HPLC). The mixture was acidified to pH 2-3 with 1N HCl, extracted with EtOAc, dried (MgSO4), evaporated, co-evaporated with toluene several times, and dried under high vacuum overnight to give the title compound (520 mg, 88%), m/z=270 (M+H)+.

1. extractionextracted with EtOAc
2. dry with materialdried (MgSO4)
3. customevaporated, co-evaporated with toluene several times
4. customdried under high vacuum overnight