反应详情

The diene 157 (0.70 g, 1.041 mmol) was dissolved in dry DCE (0.7 L). The solution was put under inert atmosphere (N2) and catalyst (Hoveyda Grubbs 2nd generation, 70 mg, 0.113 mmol) was added to the solution. The reaction mixture was refluxed for 16 h, cooled to room temperature and evaporated on silica by rotary evaporation. The product was purified by flash chromatography (heptane:ethyl acetate 1:1) which gave the title compound (0.466 g, 70%), LRMS (M+H) 645.

1. additionwas added to the solution
2. temperatureThe reaction mixture was refluxed for 16 h
3. customevaporated on silica by rotary evaporation
4. customThe product was purified by flash chromatography (heptane:ethyl acetate 1:1) which