Benzyl chloroformate → Benzyl ethyl piperidine-1,3-dicarboxylate

HRID 1443527Notes

Reaction equation

HRID 1443527 reaction equation
[NH:1]1[CH2:11][CH2:10][CH2:9][CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:2]1.C([O-])(O)=O.[Na+].Cl[C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>O>[CH2:7]([O:6][C:4]([CH:3]1[CH2:9][CH2:10][CH2:11][N:1]([C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])[CH2:2]1)=[O:5])[CH3:8]

Participants

5

Reactant 3

HCID 10387Benzyl chloroformateHCID 98969Ethyl nipecotateHCID 516892Sodium Bicarbonate

Product 1

HCID 17999271Benzyl ethyl piperidine-1,3-dicarboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
23 °C

Procedure

To a room temperature solution of 4.05 g (25.8 mmoles) of ethyl nipecotate and 4.33 g (51.5 mmoles) of NaHCO3 in water (26 mL) was added benzyl chloroformate (4.1 mL, 28.3 mmol). The reaction mixture was stirred at 23° C. under an atmosphere of N2 overnight. The crude products were diluted with water, extracted with Et2O, washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography employing a solvent gradient (hexane→70:30 hexane:EtOAc) to yield the title compound as a clear colorless oil.

Workup

  1. extractionextracted with Et2O
  2. washwashed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe crude product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-9af4b084a4d24e649ba2afdea1377383
Source dataset
uspto-grants-2010_02
Patent number
USRE041135E1

Reaction notes

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