反应详情

Dissolve 5-[5-(5-chloro-2-hydroxy-phenyl)-oxazol-2-yl]-pentanoic acid methyl ester (3.26 g, 10.52 mmol) in 50 mL of dioxane and add a solution of LiOH (1.2671 g, 50.91 mmol) in 25 mL of water to it. Allow the reaction to stir at ambient temperature for 18 hours. Acidify the reaction with 5N HCl and concentrate the reaction mixture in vacuo to remove the dioxane. Extract the aqueous residue with EtOAc (3×). Dry the combined organic layers with MgSO4. Filter off the drying agent and concentrate in vacuo to afford a crude residue. Triturate the residue in cold EtOAc. Collect the product via filtration to afford 1.8837 g of the titled product (60%): mass spectrum: m/z=296.1 (M+H).

1. customthe reaction
2. concentrationconcentrate the reaction mixture in vacuo
3. customto remove the dioxane
4. extractionExtract the aqueous residue with EtOAc (3×)
5. dry with materialDry the combined organic layers with MgSO4
6. filtrationFilter off the drying agent
7. concentrationconcentrate in vacuo
8. customto afford a crude residue
9. customTriturate the residue in cold EtOAc
10. customCollect the product
11. filtrationvia filtration