反应详情

To a mixture of 3-(3-chlorophenyl)-pyrazolo-[1,5-a]-pyrimidine-5-carboxylic acid ethyl ester (18.00 g), 120 ml of methanol, and 120 ml of tetrahydrofuran, 60 ml of a 2N aqueous sodium hydroxide solution was added, and stirred at room temperature over 2 hours. To the reactant, 60 ml of 2N hydrochloride was added dropwise, and the precipitated crystal was filtered to yield 3-(3-chlorophenyl)-pyrazolo-[1,5-a]-pyrimidine-5-carboxylic acid (14.02 g, 86%) as a yellow crystal.

1. additionwas added
2. filtrationthe precipitated crystal was filtered