Citric Acid → 2,3-Dichloro-N-{3-[4-(tetrahydro-2-pyranyloxymethyl)phenylmethoxy]-2-pyrazinyl}benzenesulphonamide

HRID 1444018Notes

Reaction equation

HRID 1444018 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:18](Cl)=[N:17][CH:16]=[CH:15][N:14]=1)(=[O:11])=[O:10].[O:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH:21]1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][OH:35])=[CH:30][CH:29]=1.CC(C)([O-])C.[K+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O1CCCC1.CN1CCCC1=O>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:18]([O:35][CH2:34][C:31]2[CH:30]=[CH:29][C:28]([CH2:27][O:26][CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25][O:20]3)=[CH:33][CH:32]=2)=[N:17][CH:16]=[CH:15][N:14]=1)(=[O:11])=[O:10]

Participants

7

Reactant 4

HCID 311Citric AcidHCID 23665647Potassium tert-butoxideHCID 591681672,3-Dichloro-N-(3-chloro-2-pyrazinyl)benzenesulphonamideHCID 67139706(4-{[(Oxan-2-yl)oxy]methyl}phenyl)methanol

Product 1

HCID 591681242,3-Dichloro-N-{3-[4-(tetrahydro-2-pyranyloxymethyl)phenylmethoxy]-2-pyrazinyl}benzenesulphonamide

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

2,3-Dichloro-N-(3-chloro-2-pyrazinyl)benzenesulphonamide (Example 28a) (0.1 g), [4-(tetrahydro-2-pyranyloxymethyl)phenyl]methanol (0.27 g) and potassium tert-butoxide (2 mL of a 1M solution in tetrahydrofuran) in N-methylpyrrolidinone (1 mL) was stirred at 50° C. After 2 h, aqueous citric acid was added and the mixture extracted with ethyl acetate. The organic solution was washed with water and brine and evaporated to dryness. Used directly.

Workup

  1. extractionthe mixture extracted with ethyl acetate
  2. washThe organic solution was washed with water and brine
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-c6d4f890fe6c411092b90cb35895dbed
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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