反应详情

Examples 146-165 were prepared using the following procedure To a solution of N-(3,5-dibromo-2-pyrazinyl)-2,3-dichlorobenzenesulphonamide (Example 31) (0.003 g) and primary alcohol (0.026 mL of a 0.5M solution in N-methylpyrrolidinone) in N-methylpyrrolidinone (0.1 mL) was added potassium tert-butoxide (0.050 mL of a 1M solution in tetrahydrofuran). The solution was allowed to stand for 24 hours. The reaction mixture was diluted with acetic acid (0.010 mL) and water (0.10 mL) and the solvents were evaporated. The residue was redissolved in dimethylsulphoxide (0.5 mL) and purified by mass directed high pressure liquid chromatography. The solvent was evaporated to afford a solid.

1. customExamples 146-165 were prepared
2. customthe solvents were evaporated
3. dissolutionThe residue was redissolved in dimethylsulphoxide (0.5 mL)
4. custompurified by mass
5. customThe solvent was evaporated
6. customto afford a solid