3-Pyridinemethanol → 2,3-Dichloro-N-[3-methoxy-5-(2-pyridinylmethoxy)-2-pyrazinyl]benzenesulphonamide Hydrochloride
Reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([O:29][CH3:30])[C:5]([N:8](COCCO[Si](C)(C)C)[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])(=[O:11])=[O:10])=[N:6][CH:7]=1.[N:31]1[CH:36]=[CH:35][CH:34]=[C:33](CO)[CH:32]=1.[H-].[Na+].CN1CCC[C:43]1=[O:47]>>[ClH:1].[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[S:9]([NH:8][C:5]1[C:4]([O:29][CH3:30])=[N:3][C:2]([O:47][CH2:43][C:36]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[CH:7][N:6]=1)(=[O:10])=[O:11]Participants
5
Reactant 4
Product 1
Procedure
Procedure as for Example 115 using N-(5-chloro-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-({2-[(trimethylsilyl)oxy]ethoxy}methyl)benzenesulphonamide (Example 115a) (0.5 g), pyridine-3-methanol (0.11 g) and sodium hydride (0.05 g of a 60% dispersion in oil) in N-methylpyrrolidinone (5 mL). Yield 0.23 g.
Sources & evidence
- ORD record
- ord-3674e466f11d421abf5f644f5d2c3d41
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07662825B2
Reaction notes
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