Benzaldehyde → N-Benzylidene(piperidin-4-yl)methanamine

HRID 1444096Notes

Reaction equation

HRID 1444096 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[NH:14]1[CH2:15][CH2:16][CH:11]([CH2:10][N:9]=[CH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 235274-(Aminomethyl)piperidine

Product 1

HCID 11820173N-Benzylidene(piperidin-4-yl)methanamine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Benzaldehyde (4.6 g; 0.044 mol) was added dropwise to a solution of 4-aminomethylpiperidine (5.0 g; 0.044 mol) in toluene (20 ml). The solution thus obtained was stirred for 3 h at room temperature. Then the solvent was removed by evaporation at reduced pressure and the residue was taken up twice with toluene to give the desired product that was used as such without further purification.

Workup

  1. customThe solution thus obtained
  2. customThen the solvent was removed by evaporation at reduced pressure

Sources & evidence

ORD record
ord-5924d5348ad944b5b28619e072e9943f
Source dataset
uspto-grants-2010_02
Patent number
US07662836B2

Reaction notes

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