反应详情

Heat a mixture of 4-chloro-6-(3-chloro-4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl) -pyrimidine (210 mg), 1-(3-Methyl-5-nitro-pyridin-2-yl)-piperazine, and DIEA (185 mg, 1.44 mmol) in DMA at 120°C. for 16 h. Concentrate under reduced pressure and partition between EtOAc and brine. Dry the organic layer (Na2SO4) and concentrate under reduced pressure. Purify the residue by flash column eluting with EtOAc-Hexanes (1:4) to afford the title compound as a yellow solid.

1. temperatureHeat
2. concentrationConcentrate under reduced pressure
3. custompartition between EtOAc and brine
4. dry with materialDry the organic layer (Na2SO4)
5. concentrationconcentrate under reduced pressure
6. customPurify the residue by flash column
7. washeluting with EtOAc-Hexanes (1:4)