反应详情

Heat a mixture of 4-(3-chloro-4-fluoro-phenyl)-6-piperazin-1-yl-2-(4-propyl-piperazin-1-yl)-pyrimidine (300 mg, 0.72 mmol), 2-chloro-3-methyl-5-nitro-pyridine (149 mg, 0.86 mmol) and DIEA (186 mg, 1.44 mmol) in DMA (4 mL) for 16 h at 110° C. Cool, partition between 10% NaOH and EtOAc and wash the organic layer with additional NaOH solution (3×). Dry the organic layer (Na2SO4) and concentrate under reduced pressure to afford the title compound.

1. temperatureHeat
2. temperatureCool
3. custompartition between 10% NaOH and EtOAc
4. washwash the organic layer with additional NaOH solution (3×)
5. dry with materialDry the organic layer (Na2SO4)
6. concentrationconcentrate under reduced pressure