反应详情

24 mg of the compound from Example 22 (0.04 mol) are dissolved in 2.0 ml of THF/methanol (1:1). 0.1 ml of 1 N sodium hydroxide solution is added, and the reaction mixture is stirred at room temperature for 16 h. It is diluted with water and acidified with 1 N hydrochloric acid, and the mixture is extracted three times with dichloromethane. The combined organic phases are dried over sodium sulphate, and the solvent is removed in a rotary evaporator. 23 mg (100% of theory) of the title compound are obtained.

1. extractionthe mixture is extracted three times with dichloromethane
2. dry with materialThe combined organic phases are dried over sodium sulphate
3. customthe solvent is removed in a rotary evaporator