3-Phenyl-2-propyn-1-ol → Benzenepropanol

HRID 1444856Notes

Reaction equation

HRID 1444856 reaction equation
[H][H].[C:3]1([C:9]#[C:10][CH2:11][OH:12])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C1COCC1>[C:3]1([CH2:9][CH2:10][CH2:11][OH:12])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 1231153-Phenyl-2-propyn-1-ol2×HCID 178418361HCID 178418361, compound

Product 1

HCID 31234BenzenepropanolYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In Example 6, hydrogenation reaction was conducted under the same condition as Example 1 for THF diluted solution concentration of the substance to be reduced, its flow rate, and hydrogen 9 flow rate, using 3-phenyl-2-propin-1-ol as the substance to be reduced. The reaction time was within five minutes. The analytical result of the reaction product by 1H-NMR showed almost complete hydrogenation of 3-phenyl-2-propin-1-ol, and 3-phenyl-1-propanol was obtained at about 100% yield (See FIG. 6.).

Workup

  1. customIn Example 6, hydrogenation reaction
  2. customThe analytical result of the reaction product

Sources & evidence

ORD record
ord-b3b448576afe4281bec35b958391d547
Source dataset
uspto-grants-2010_02
Patent number
US07663008B2

Reaction notes

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