Hydrochloric Acid → HCID 67142381, compound

HRID 1445085Notes

Reaction equation

HRID 1445085 reaction equation
[CH3:1][C:2]1[NH:20][C:5]2=[C:6]([N:10]3[CH2:19][CH2:18][C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[CH2:11]3)[N:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[S:21][CH3:22].[ClH:23]>C(OCC)(=O)C>[ClH:23].[CH3:1][C:2]1[NH:20][C:5]2=[C:6]([N:10]3[CH2:19][CH2:18][C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[CH2:11]3)[N:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[S:21][CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67142286HCID 67142286, compound

Product 1

HCID 67142381HCID 67142381, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-(2-methyl-3-methylsulfanyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline prepared in Step 2 in ethyl acetate was saturated with hydrochloric acid gas and then filtered to give the titled compound as a white solid (Yield: 54%)

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-651464023cd645e6ac3783a9141c38b6
Source dataset
uspto-grants-2010_02
Patent number
US07662832B2

Reaction notes

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