反应详情

温度

22 °C

1.16 g of methyl 3-benzyloxy-5-isopropyl-thiophene-2-carboxylate were dissolved in 10 ml of tetrahydrofuran (THF) and 10 ml of methanol, and a solution of 1.7 g of lithium hydroxide in 10 ml of water was added. The reaction mixture was stirred at 22° C. for 72 h. Methanol and THF were stripped off in the rotary evaporator. While cooling in ice, the reaction mixture was adjusted to pH=4 with 2 molar hydrochloric acid and extracted twice with 50 ml of ethyl acetate each time. The combined organic phases were dried over sodium sulfate and concentrated.

1. customMethanol and THF were stripped off in the rotary evaporator
2. temperatureWhile cooling in ice
3. extractionextracted twice with 50 ml of ethyl acetate each time
4. dry with materialThe combined organic phases were dried over sodium sulfate
5. concentrationconcentrated